Clinical Genomics Center

  • Mission and Objectives
  • Activities
  • Tools and Equipment
  • Future Events
  • Previous Events
  • Personnel
  • Galleries

Mission and Objectives

Mission

Alexandria Faculty of Medicine Clinical Genomics Center a Center of Excellence in Medical Genetics offering medical genetics service at the highest international standards and establishing high quality collaborative research with highly competent and experienced international centers aiming to incorporate medical genetics in the health care system provided at Alexandria Faculty of Medicine.

Objectives

There are three main objectives to work on:
1. Provide Medical Genetics Service
2. Educational and academic activities
3. Research

Activities

1. Medical Genetics Service

1. Offer multidisciplinary genetics services for diagnosis and counseling.

2. Integration among different disciplines to provide the service.

3. Organizing the establishment of laboratory services for genetic tests and application of quality control measures and ensuring quality assurance at international standards.

4. Interpretation of genetic test results and review case diagnosis with clinical specialists.

5. Establish genetic disorders database to target health care efforts according to community needs.

6. Cancer Genetics medical services.

 2.Research

Postgraduate candidates of different specialties undertaking their MSc or MD thesis in the field of genetics use the facilities available at AFM CG Centre. In addition to collaborative international research in the field of high technology genomic research.

3. Laboratory Genetics

AFM CG is planning to adopt quality management systems to meet international accreditation standards. In addition there is provision of training on undertaking different genetic testing and interpretation and reporting of results.

The center is the first specialized University Hospital Center to offer neonatal screening of congenital hypothyroidism, phenylKetonuria and galactosemia. Currently the Center is prepared to offer prenatal screening for high risk pregnancy offering biochemical marker detection using standardized time resolved fluorescence technique for screening for trisomies and neural tube defect. These screening tests require pre and post-test genetic counselling and this service is offered at the Clinical Genomics Centre. The Centre will be prepared for offering such a high quality service in collaboration with the Ministry of health.

Offering this service would allow epidemiologic studies to be undertaken to identify the incidence and prevalence of genetic disorders which can be considered as individually rare but collectively common in our community. This would help policy makers and stakeholders to prioritise services and to target our community health problems.

4.Educational

1. Basic medical genetics included in the undergraduate education of medical students.

2. Upgrade the curriculum of postgraduate studies in medical genetics.

3. Hold national and international conferences and symposia in conjunction with National and International collaborators.

Tools and Equipment

Tool

Usage

1

 UV-Transilluminator  Nucleic Acid Visualization on Ethidium Bromide stained gels

2

 Submarine Mini Gel Electrophoresis  Agarose gel electrophoresis for detection of nucleic acid and PCR products

3

 Electrophoresis Power Supply  Used in Electrophoresis

4

 Autoclave  Sterilization of Lab ware

5

 Water Bath  For Thermal adjusted incubations

6

 Thermal Cycler “Bio Cycler” (PCR)  For automated thermal cycling (PCR)

7

 Wallac System

 Wallac VICTOR 2 D + adjoined computer (fluorescent plate redden)

 Automatic Dispenser
Puncher

 Washer & Remover

 Incubator
 In Biochemical Genetics for screening of metabolic disorders such as :

 Phenylketonuria , Galactosemia , Cystic fibrosis

 Hormonal assay – Prenatal screening assay:

 First Trimester     ( B HCG  –  PAPP-A )
Second Trimester (AFP  –  HCG  –  Eu3)

Guthrie card automated puncher for reliability & high through put newborn

Screening

Newborn and Prenatal screening protocols

96 well – plate thermal incubator & shaker

8

 Nucleic Acid Fragment Analyzer e-Gene  12 Capillary semi-quantitative electrophoresis for high  through put analysis of nucleic acid up to 95 samples in single run

9

 Protein electrophoresis + Power Supply + canon scanner  For Hb electrophoresis and diagnosis of hereditary hemoglobinopathies(carriers & cases)

10

 Distillator  For water distillation

11

 Mini – Rocker   MR-1  Rocking shaking for staining trays

12

 Vortex  Vortexing for adequate mixing & suspension preparation

13

 Magnetic Stirrer  For solution preparation

14

 Sensitive Balance  Weighing chemicals

15

 Biological Safety Cabinet  Class II safety cabinet for hygienic handling of biological samples

16

 Freezer -85⁰C  Related to research projects & establishing Biobanking

17

 Freezer -75⁰C

18

 pH meter  Measuring PH

19

 Microwave

20

 Micro Centrifuge

21

 Centrifuge

Future Events

Previous Events

First Workshop:

“A Future Glimpse on Metabolic Genetic Diseases in the Newborn”

Date: 15/3/2008

No. of Attendants: 129

 

Second Workshop:

“Metabolic Storage Diseases: Clinical Genetic Perspective”

Date: 1/12/2008

No. of Attendants: 83

 

Third Workshop:

“Genetic Language for Clinicians”

Date: 18/5/2009

No. of Attendants: 129

 

Fourth Workshop:

“Nano Biotechnology Workshop “conducted along the Faculty Annual Congress 2009

Date: 13 -15/6/2009

No. of Attendants: 30

Personnel

Faculty of Medicine, Alexandria University has obtained a Ministry of High Education Decree in 1993 of introducing Clinical Genetics into the postgraduate degrees granted by AFM. Accordingly posts were advertised and AFM appointed two Clinical Genetics staff members in 1994 and 1995. Clinical Geneticist have a pivotal role in every day activity of the center and organizes interdisciplinary service and consultation from various clinical specialties.

The Staff Team

Board

 

The Executive Director: Dr. Heba Kassem, Assistant Professor of Clinical Genetics

Consultants:

1. Vice Dean of Postgraduate Studies Professor Seddik Abdel Salam
2. Vice Dean for Education and Student Affairs
3. Professor Aziz Belal: Professor of ENT and ExDean of Alexandria Faculty of Medicine
4. Professor Ahmed Shawky: Director of the New University Hospital
5. Professor Iman Marzouk: Professor of Pediatrics
6. Professor Shawky Tayel: Professor of Anatomy and Embryology

Staff Members:

1. Dr. Manal El Banna: Senior Lecturer of Phoniatics
2. Dr. Hoda El Aasi: Assistant Lecturer of Clinical Genetics
slide