Ionotropic glutamate receptors (iGluRs) of the delta family (GluD1 and GluD2) and synaptogenesis

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Muhammad Zahid Khan


Glutamate delta-1 (GluD1) and glutamate delta-2 (GluD2) form the delta family of
ionotropic glutamate receptors (iGluRs) and are distinct from other (iGluRs) in that they do not
exhibit typical agonist-induced ion channel currents. Recent studies have demonstrated a crucial
role of the delta receptors in synapse formation by interacting with presynaptic proteins such as
Neurexin1. This review presents current knowledge regarding the expression, structure and function
of Glu delta receptors (GluD1, GluD2) in brain, focusing on synapse formation, function and dysfunction.
2016 Alexandria University Faculty of Medicine. Production and hosting by Elsevier B.V. This is an
open access article under the CC BY-NC-ND license (

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Author Biography

Muhammad Zahid Khan

Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, China