In vitro antioxidant, hypoglycemic and oral glucose tolerance test of banana peels

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V.V Navghare S.C Dhawale


Banana fruit is claimed to have antidiabetic effects despite its high calorie content, and
its peels also contain vital phytoconstituents including gallocatechin. Previously banana pulp has
been studied for antihyperglycemic effects, and in the present investigation antihyperglycemic effect
of ethanolic extract of inner peels of Musa sapientum (EMS), Musa paradisiaca (EMP), Musa
cavendish (EMC) and Musa acuminata (EMA) fruit was evaluated using oral glucose tolerance test
in normoglycemic rats. In vitro antioxidant study was conducted using DPPH, H2O2 radical scavenging
assay and ferric reducing power assay. Wistar rats were divided into fourteen groups and
twelve groups received different doses of aforementioned extracts, while control group received
gum acacia solution and remaining group received standard drug, glimepiride. All the rats received
glucose load at a dose of 2 g/kg body weight. Groups treated with EMC and EMA showed significant
decrease in glucose level (p< 0.01) at 150 min as compared to control group. In hypoglycemic
study, only EMP 500 mg/kg, p.o. treated group revealed a significant decrease (p< 0.05) in glucose
level at 120 min, while other groups did not show any sign of hypoglycemia. In glucose tolerance
test, animals treated with EMC and EMA depicted dose dependent antihyperglycemic effect at
150 min while EMS and EMP showed significant reduction in plasma glucose at higher doses. In
a similar fashion, EMA i.e. M. acuminata demonstrated highest antioxidant activity followed by
EMC against DPPH radical. In ferric reducing power and H2O2 scavenging assay, EMA demonstrated
maximal antioxidant activity when compared with other extracts.
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Author Biographies

V.V Navghare

Department of Pharmacology, School of Pharmacy, S.R.T.M. University, Nanded 431606, Maharashtra, India

S.C Dhawale

Department of Pharmacology, School of Pharmacy, S.R.T.M. University, Nanded 431606, Maharashtra, India